Molecular drug targets

Anna Weinzinger
University of Vienna (Universität Wien)
Department für Pharmakologie und Toxikologie, Department of Pharmacology and Toxicology

VSC project / type: 70405 / funded

VSC-1 / status: 2014-03-07 - 2015-03-28 / finished
VSC-2 / status: 2013-03-11 - 2019-03-15 / active

Publications:

  • Gardner Alison, Wu Wei, Thomson Steven, Zangerl-Plessl Eva-Maria, Stary-Weinzinger Anna, Sanguinetti Michael
    Molecular basis of altered hERG1 channel gating induced by ginsenoside Rg3.
    Molecular pharmacology None, (2017)

  • Bernsteiner Harald, Brundl Michael, Stary-Weinzinger Anna
    Dynamics of the EAG1 K
    Biochemical and biophysical research communications 484, 107 (2017)

  • Saxena P., Zangerl-Plessl E. -M., Linder T., Windisch A., Hohaus A., Timin E., Hering S., Stary-Weinzinger A.
    New potential binding determinant for hERG channel inhibitors
    SCIENTIFIC REPORTS 6, 24182 (2016)

  • Lee Sun-Joo, Ren Feifei, Zangerl-Plessl Eva-Maria, Heyman Sarah, Stary-Weinzinger Anna, Yuan Peng, Nichols Colin G
    Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
    The Journal of general physiology 148, 227 (2016)

  • Linder Tobias, Bernsteiner Harald, Saxena Priyanka, Bauer Florian, Erker Thomas, Timin Eugen, Hering Steffen, Stary-Weinzinger Anna
    Drug trapping in hERG K+ channels: (not) a matter of drug size?
    MEDCHEMCOMM 7, 512 (2016)

  • Linder Tobias, Wang Shizhen, Zangerl-Plessl Eva-Maria, Nichols Colin G., Stary-Weinzinger Anna
    Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels
    JOURNAL OF CHEMICAL INFORMATION AND MODELING 55, 814 (2015)

  • Linder Tobias, Saxena Priyanka, Timin Eugen, Hering Steffen, Stary-Weinzinger Anna
    Structural Insights into Trapping and Dissociation of Small Molecules in K+ Channels
    JOURNAL OF CHEMICAL INFORMATION AND MODELING 54, 3218 (2014)

  • Lukacs Peter, Gawali Vaibhavkumar S., Cervenka Rene, Ke Song, Koenig Xaver, Rubi Lena, Zarrabi Touran, Hilber Karlheinz, Stary-Weinzinger Anna, Todt Hannes
    Exploring the Structure of the Voltage-gated Na+ Channel by an Engineered Drug Access Pathway to the Receptor Site for Local Anesthetics
    JOURNAL OF BIOLOGICAL CHEMISTRY 289, 21770 (2014)

  • Ke Song, Timin E. N., Stary-Weinzinger Anna
    Different Inward and Outward Conduction Mechanisms in NaVMs Suggested by Molecular Dynamics Simulations
    PLOS COMPUTATIONAL BIOLOGY 10, e1003746 (2014)

  • Ke Song, Stary-Weinzinger Anna
    A Novel Gating Mechanism of the NaVMs Selectivity Filter Suggested by Molecular Dynamics Simulations
    BIOPHYSICAL JOURNAL 106, 131A (2014)

  • Ke Song, Zangerl Eva-Maria, Stary-Weinzinger Anna
    Distinct interactions of Na+ and Ca2+ ions with the selectivity filter of the bacterial sodium channel Na(v)Ab
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430, 1272 (2013)



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